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Academy Award winner Angelina Jolie stars as Sarah Jordan, an American living in London who is trapped in an unhappy marriage to the son of a wealthy banker. But one night at a charity event she meets Nick Callahan (Clive Owen), a renegade doctor running dangerous relief efforts in war-torn nations.Drawn to this charismatic and outspoken advocate and inspired by his extraordinary work, Sarah is compelled to take the biggest gamble of her life! She embarks on an incredible journey through the ravaged deserts of Ethiopia, the deadly jungles of Cambodia and the treacherous battle zones of Chechnya. Amidst this carnage, she discovers in Nick a role-model of compassion and a soul-mate for life.Spanning a decade and set against a turbulent backdrop of civil war, revolution, famine and corruption, this is an epic tale of unspeakable suffering, uncommon valour and undying passion.