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Season six is the season of change, when C.J. (Allison Janney) becomes chief of staff, President Bartlet (Martin Sheen) suffers a debilitating attack of multiple sclerosis, and Josh (Bradley Whitford) leaves the White House to run Matt Santos’ (Jimmy Smits) presidential campaign. The presidential race is on, with Senator Arnold Vinick (Alan Alda) as the Republican frontrunner and a Matthew Santos (Jimmy Smits) vying for the hotly contested Democratic presidential nomination.